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GDF15及其受体作为调解吸烟相关体重变化的途径
Alexander C Tinworth1, Andri Iona1, Pang Yao1
1Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
EBioMedicine
|June 17, 2025
概括
增长/差异化因子15 (GDF15) 中介于与吸烟相关的体重变化. 准GDF15可能有助于戒烟,并防止体重增加.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
背景情况:
- 吸烟者体重较低;戒烟导致体重增加,需要对潜在机制进行研究.
- 确定治疗目标可以提高戒烟的成功率,并减轻体重增加.
研究的目的:
- 调查GDF15及其受体在调解吸烟相关体重变化的作用.
- 评估GDF15及其受体 (RET,GFRAL),吸烟和肥胖之间的关联.
主要方法:
- 在3936名中国成年人中,使用Olink和SomaScan平台测量了血GDF15,RET和GFRAL水平.
- 线性回归评估了蛋白质,吸烟和肥胖之间的关联.
- 两个样本的门德尔随机化 (MR) 分析利用吸烟强度的遗传变异来探索与脂肪和蛋白质水平的因果关系.
主要成果:
- 吸烟者比不吸烟者有较低的BMI;前吸烟者BMI和肥胖度最高.
- 吸烟与GDF15和GDF15/受体比率正相关;GDF15水平随着吸烟强度的增加而增加.
- 核磁共振分析显示,吸烟强度与降低的BMI (东亚人) 和更高的GDF15水平 (东亚人和欧洲人) 有因果关系.
- GDF15部分调解了吸烟与肥胖的关联;GDF15/RET比率显示出更强大的调解效应.
结论:
- 在中国成年人中,GDF15在调解吸烟相关体重变化方面发挥着重要作用.
- GDF15及其受体相互作用为促进戒烟和控制体重增加提供了潜在的治疗点.
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