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Updated: Sep 19, 2025

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

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基于单细胞和批量测序的多发性骨髓瘤中与DNA损伤修复 (DDR) 相关的预后风险模型

Hongxiu Liu1, Zhihua Li2, Yihua Wang3

  • 1Second Clinical Medical College, Shanxi Medical University, Taiyuan City, China; Department of Hematology, The Second Clinical Medical College of Shanxi Medical University, Shanxi Medical University, Taiyuan, China.

DNA repair
|June 17, 2025
PubMed
概括

这项研究确定了DNA损伤修复 (DDR) 基因表达作为多发性骨髓瘤 (MM) 结果的预测因素. 一个新的风险模型突出了潜在的治疗向和改善患者分层的关键DDR基因.

关键词:
生物信息学是一种生物信息学.生物标志物生物标志物大量测序批量测序修复DNA损伤的修复药物敏感性预后 药物敏感性预后免疫系统的透.多发性骨髓瘤是一种多发性骨髓瘤.预测的签名预测的签名单细胞RNA测序的一个细胞.

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DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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