亲炎性IL-1β:慢性 chikungunya关节炎疾病的潜在生物标志物
Subrat Thanapati1, Shruti Kulkarni1, Tanvi Shinde1
1Department of Dengue and Chikungunya, Indian Council of Medical Research-National Institute of Virology, 20-A, Dr Ambedkar Road, Pune 411 001, India.
Human immunology
|June 17, 2025
概括
介素-1β (IL-1β) 是慢性 chikungunya 关节炎的一个潜在生物标志物. 抑制颗粒细胞-巨细胞殖民地刺激因子 (GM-CSF) 可能治疗 chikungunya 相关的炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生物标志物发现发现
背景情况:
- 细胞因子和化学因子是 chikungunya 病毒 (CHIKV) 免疫反应的关键.
- 了解跨CHIKV疾病阶段的特定细胞因子生物标志物是不完整的.
研究的目的:
- 在急性,慢性和已治愈的奇昆古尼亚病毒 (CHIKV) 感染中识别细胞因子和化学因子.
- 确定 chikungunya 关节炎的潜在生物标志物,并探索治疗点.
主要方法:
- 在患者组和健康对照中评估了17种CHIKV特异性细胞因子/化学因子分析物.
- 在外周血液单核细胞 (PBMC) 超级生物中测量分析物,这些超级生物被激活了无活化的CHIKV.
- 利用ROC分析来识别潜在的生物标志物.
主要成果:
- 慢性 chikungunya 关节炎患者显示IL-1β,IL-6和GM-CSF的升高.
- 通过ROC分析,IL-1β被确定为慢性 chikungunya关节炎的潜在生物标志物.
- 在急性患者中,IFN-γ与CHIKV负载有负相关性;在康复患者中,IL-12和IFN-γ较高.
结论:
- IL-1β是慢性 chikungunya 关节炎的潜在生物标志物.
- 抑制GM-CSF可能是治疗CHIKV相关炎症的治疗策略.
- 进一步研究IL-12和IFN-γ在CHIKV解析中的作用是有必要的.
相关概念视频
The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...


