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来自Gynostemma pentaphyllum callus的多氧核酸对皮肤屏障功能的影响

Euihyun Kim¹, Sunmee Choi¹, Jihyeon Jang¹

¹Plant Cell Research Institute of BIO-FD&C Co. Ltd., Incheon, 21990, Republic of Korea.

Biochemical and biophysical research communications

|June 17, 2025

概括

来自Gynostemma pentaphyllum的植物衍生型聚二氧化碳核酸 (PDRN) 显示出作为纯素替代鱼衍生型PDRN的有前景. 这种新型成分支持皮肤再生,增强皮肤屏障,与传统的PDRN相比.

科学领域:

生物技术和皮肤病学
来自植物的生物材料

背景情况:

从鱼精子中提取的多氧化核酸 (PDRN) 在生物医学和化品应用中用于通过腺A2A受体结合进行组织再生.
与动物衍生的PDRN相关的伦理和可持续性问题需要开发基于植物的替代品.

研究的目的:

为了研究从Gynostemma pentaphyllum (GyPen) 提取的植物衍生PDRN (GP) 作为鱼衍生PDRN (SP) 的纯素替代品的潜力.
评估GP在增强皮肤屏障功能和促进皮肤再生中的疗效.

主要方法:

使用基于植物的方法从Gynostemma pentaphyllum中提取GP.
在皮肤细胞 (角质细胞) 上进行GP的体外评估,以评估活力,抗氧化剂和伤口愈合特性.
使用转录组和qRT-PCR分析皮肤屏障蛋白表达 (FLG,IVL,CLDN1) 和基因调控.

主要成果:

GP显著改善了角质细胞的活力,显示了与SP相比的抗氧化和伤口愈合效应.
医生治疗上调了关键的皮肤屏障蛋白 (FLG,IVL) 和调节了CLDN1表达,表明皮肤屏障功能得到了增强.
转录和qRT-PCR分析证实了GP对皮肤屏障相关基因的显著调节.

结论:

来自Gynostemma pentaphyllum的植物衍生的PDRN (GP) 是一种可行的纯素替代品,可以替代鱼衍生的PDRN (SP).
GP有效地支持皮肤再生,并加强皮肤屏障,为皮肤健康和防止压力因素提供潜在的益处.

关键词:

吉诺斯泰玛五叶植物 (Gynostemma pentaphyllum) 是一种植物.聚二氧化核酸是多氧化核酸的一种.鱼鱼鱼鱼是一种皮肤障碍物皮肤障碍物伤口愈合伤口愈合

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