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易挥发性有机化合物暴露,生物衰老和增加的肉症风险:关联,相互作用和机械探索
1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
暴露于挥发性有机化合物 (VOCs) 与增加肉症风险有关,特别是在老年人中. 这项研究确定了特定的VOC代谢物和TNF信号通路作为关键因素,突出了环境毒素和生物衰老之间的相互作用.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 毒理学 毒理学 毒理学
背景情况:
- 萨科佩尼亚是一种与年龄相关的重大健康问题,对环境有毒物质影响的了解有限.
- 挥发性有机化合物 (VOC) 是无处不在的环境毒素,对肉类风险的影响基本上尚不清楚.
研究的目的:
- 调查暴露于特定挥发性有机化合物代谢物 (VOCMs) 和成年人肉症之间的关联.
- 探索多种VOCM的综合作用及其与生物衰老 (PhenoAge) 相互作用对肉类风险的影响.
- 阐明潜在的潜在生物机制,包括瘤亡因子 (TNF) 信号通路.
主要方法:
- 分析了来自3007名美国成年人的数据 (国家健康和营养检查调查,2011-2018).
- 应用多变量逻辑回归,加权量子总和 (WQS) 和贝叶斯内核机器回归 (BKMR) 模型.
- 利用网络药理识别生物途径和表型年龄 (PhenoAge) 来评估生物衰老相互作用.
主要成果:
- 包括ATCA,CEMA,DHBMA和3,4MHA在内的几种VOCM单独与增加的肉类风险有关.
- 16种VOCM的混合物显示出与较高的肉症风险有显著的关联 (OR: 1.79,95% CI: 1.30-2.49).
- 现型年龄 (PhenoAge) 与缩症风险升高和放大VOCM效应 (P相互作用<0.05) 有关;TNF信号传递被确定为关键途径.
结论:
- 这项研究提供了第一个证据,将挥发性有机化合物暴露与增加的肉症风险联系起来.
- 挥发性有机化合物暴露和生物衰老之间的相互作用加剧了肉症的风险,可能是通过TNF信号通路.
- 这些发现为 Sarcopenia 预防策略提供了新的见解,考虑到环境中毒物暴露和衰老.
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