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作为多方面抗糖尿病药物的胺基衍生物:结构-活性关系,机制和临床潜力的综合性审查

Mohammed A Marzouk1

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.

European journal of medicinal chemistry
|June 17, 2025
PubMed
概括

胺衍生物通过向DPP-4抑制和GLP-1激活等关键途径,显示出对糖尿病治疗的希望. 本综述分析了它们的结构-活性关系,以提高新型抗糖尿病疗法的疗效和多目标潜力.

关键词:
抗糖尿病药物 抗糖尿病药物DPP-4 抑制剂的使用分子对接是分子对接.多目标药物设计.皮里米丁衍生品 皮里米丁衍生品结构与活动关系 (SAR)α-葡萄糖酶抑制的抑制

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