与使用大麻和大麻素相关的心血管风险:系统性审查和元分析
Wilhelm Storck1,2, Meyer Elbaz3,4,5, Cécile Vindis4,5
1CERPOP, University of Toulouse, Inserm, Toulouse, Occitanie, France.
Heart (British Cardiac Society)
|June 17, 2025
概括
大麻使用与心血管风险增加有关,包括急性冠状动脉综合征,中风和心血管死亡. 医疗保健提供者应评估心血管疾病患者的大麻使用情况.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 人们越来越担心与大麻使用相关的心血管健康风险.
- 在全球范围内,大麻和大麻类药物消费日益普遍.
研究的目的:
- 系统地审查和元分析大麻使用与主要不良心血管事件 (MACE) 之间的关联.
- 评估大麻使用者的心血管死亡,急性冠状动脉综合征 (ACS) 和中风风险.
主要方法:
- 从2016-2023年对药物流行病学研究进行系统审查,搜索PubMed,科学网和Scopus.
- 包括24篇文章 (17个横截面,6个队列,1个病例控制) 评估与大麻相关的MACE.
- 分析使用随机效应模型将心血管死亡,ACS和中风的调整效应估计汇集在一起.
主要成果:
- 大麻使用与心血管疾病风险增加有关 (RR=1.29,95% CI 1.05-1.59),中风 (RR=1.20,95% CI 1.13-1.26) 和心血管死亡 (RR=2.10,95% CI 1.29-3.42).
- 对于ACS和中风的复合结果,没有发现显著的关联.
- 队列研究分析证实了可比结果 (RR=1.32,95% CI 1.01-1.73).
结论:
- 这一元分析表明,大麻使用和MACE之间存在积极的关联.
- 这些发现支持在患有心血管疾病的患者中调查大麻使用情况.
- 现实世界的数据凸显了需要提高人们对大麻相关心血管风险的认识.
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