相关实验视频

Updated: Sep 19, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

心脏相位选择对计算流体动力学分析的影响

Jin Zheng¹, Xinxin Yu², Quanlin Sun³

¹Department of Radiology, University of Cambridge, Cambridge, UK; MRC Laboratory of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK.

Journal of cardiovascular computed tomography

|June 17, 2025

概括

在冠状动脉计算机断层扫描血管学 (CCTA) 中心脏相位选择显著影响TAWSS,OSI和RRT等计算流体动力学 (CFD) 度量. 标准化这一阶段对于基于CCTA的CFD分析准确和一致至关重要,特别是在异常冠状动脉中.

科学领域:

心血管成像 - 心血管成像
生物医学工程生物医学工程
计算流体动力学的流体动力学.

背景情况:

在冠状动脉计算机断层扫描血管造影 (CCTA) 中的心脏相位选择可以影响计算流体动力学 (CFD) 衍生的血液动力学指标.
这种影响尚未得到充分量化,特别是在冠状动脉异常患者中.

研究的目的:

评估心脏相位选择对正常和异常冠状动脉CF结果的影响.
量化不同冠状动脉解剖学中的血液动力学指标的相位依赖性.

主要方法:

来自40名患者的多相CCTA数据集的分析 (包括正常,异常的右冠状动脉[ARCA]和心肌桥梁[MB]解剖学).
计算CFD衍生参数:时间平均壁切削应力 (TAWSS),振荡切削指数 (OSI),相对停留时间 (RRT) 和CCTA衍生分流储备 (CT-FFR).
通过比较不同心脏阶段和不同患者组的测量来评估相位依赖性.

主要成果:

发光面积差异显示了各阶段之间显著的群体距离相互作用.
振荡剪切指数 (OSI) 的差异在心肌桥梁 (MB) 患者中较小,与正常对照组相比.
虽然TAWSS,OSI和RRT表现出相位依赖性,但CCTA衍生的分流储备 (CT-FFR) 显示出较低的变化,对于相对于零的任何参数都没有观察到显著差异.

结论:

冠状动脉几何学显示了明显的相位依赖性,影响了血液动力学分析.
在基于CCTA的CFD分析中,TAWSS,OSI和RRT的阶段依赖性需要仔细考虑.
标准化心脏相位选择对于提高CCTA衍生CFD结果的准确性和临床一致性至关重要.

关键词:

计算机断层扫描血管图谱.冠状动脉的冠状动脉分量流量储备部分流量储备阶段阶段阶段阶段墙壁剪切应力压力是什么

更多相关视频

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

相关概念视频

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...

Typical Model Studies

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...