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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

5.9K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
5.9K
T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Guidelines for T cell nomenclature.

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Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility.

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Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8<sup>+</sup> thymocytes.

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The cellular microenvironment regulates CX3CR1 expression on CD8<sup>+</sup> T cells and the maintenance of CX3CR1<sup>+</sup> CD8<sup>+</sup> T cells.

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Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.

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Linking asymmetric cell division, CD8<sup>+</sup> T cell fate, and signal strength.

Cell reports·2023
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IL-33 scripts cancer immunity.

Trends in immunology·2026
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Mitochondrial Ca<sup>2+</sup> signaling: A metabolic rheostat defining tumor and immune cell fate.

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Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations.

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相关实验视频

Updated: Sep 19, 2025

Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

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在T细胞子设置挑战的挑战.

Natalia R Comet1, Carmen Gerlach2

  • 1Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, and Karolinska University Hospital, and Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden.

Trends in immunology
|June 17, 2025
PubMed
概括
此摘要是机器生成的。

了解T细胞子集是有效的T细胞治疗的关键. 这项研究阐明了复杂的T细胞定义和标记,帮助研究人员导航T细胞分类以改善治疗策略.

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

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相关实验视频

Last Updated: Sep 19, 2025

Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

52.7K
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry
10:58

Discrimination of Seven Immune Cell Subsets by Two-fluorochrome Flow Cytometry

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 治疗方法 治疗方法

背景情况:

  • 针对特定的T细胞子集对先进的免疫疗法具有前景.
  • 目前T细胞疗法发展的挑战源于对T细胞子集的不一致的定义和标记.

研究的目的:

  • 分析定义和分类T细胞子集的复杂性.
  • 为在研究和临床应用中导航T细胞子集识别的复杂性提供指导.

主要方法:

  • 对T细胞子集分类系统的文献综述和概念分析.
  • 讨论T细胞标记物表达和功能定义中现有的差异.

主要成果:

  • 确定了导致T细胞子集定义含糊不清的关键因素.
  • 强调了不一致的分类对基于T细胞的疗法的可重现性和疗效的影响.

结论:

  • 标准化定义和强大的标记面板对于推进T细胞疗法至关重要.
  • 需要一个明确的T细胞亚群分类框架来克服当前的治疗局限性.