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Updated: Sep 19, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Published on: December 19, 2018

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通过非传统的联合激活剂结合位点 (CBS) 来向降解雌激素受体α

Yubo Wang1, Baohua Xie1, Xiaofei Deng1

  • 1Department of Hematology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.

Journal of medicinal chemistry
|June 17, 2025
PubMed
概括

研究人员开发了针对雌激素受体α (ERα) 的新型PROTAC,以对抗ERα阳性乳腺癌中的内分泌抵抗. 化合物CP03有效降解ERα并抑制癌细胞生长,为新的治疗策略显示出希望.

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