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Updated: Sep 19, 2025

Purification of Endogenous Drosophila Transient Receptor Potential Channels
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在不同状态下的TRPML2揭示了TRPML家族的激活和调制原理

Philip Schmiege1, Dawid Jaślan2, Michael Fine3

  • 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature communications
|June 17, 2025
PubMed
概括

这项研究揭示了TRPML2通道激活器如何结合和功能,揭示了一个独特的π-凸过渡机制. 这些发现为开发用于内分泌体调节的选择性TRPML调节剂铺平了道路.

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