在患有发作的儿童的MRI (VABAM) 上,维加巴特林相关的大脑异常
Ali Mir1, Fawzia Amer2,3, Manar AlOtaibi2
1Department of Pediatric Neurology, King Fahad Specialist Hospital, Dammam, Saudi Arabia. kashifalishazm@moh.gov.sa.
Pediatric research
|June 17, 2025
概括
在患有发作的儿童中,MRI (VABAM) 上的维加巴特林相关的大脑异常很常见,特别是服用较高剂量的年轻患者. 这些变化往往是可逆的,但在MRI扫描中经常被误诊.
科学领域:
- 神经学 神经学
- 儿科神经学 儿科神经学
- 神经辐射学神经辐射学
背景情况:
- 维加巴特林用于治疗性 (ES).
- 在vigabatrin治疗期间,MRI (VABAM) 上的脑部异常可能发生.
- 确定VABAM的风险因素对于患者管理至关重要.
研究的目的:
- 为了确定VABAM的风险因素.
- 在VABAM患者中描述大脑MRI变化的模式.
- 评估ES儿童中VABAM的流行率.
主要方法:
- 对ES治疗vigabatrin的患者进行了回顾性观察性研究.
- 纳入标准:在维加巴林治疗期间至少进行一次MRI.
- 分析MRI异常,它们的位置,并比较VABAM阳性和VABAM阴性组之间的风险因素.
主要成果:
- 在vigabatrin治疗期间接受MRI的患者中,44.7%的患者显示VABAM.
- 维加巴特林开始时的年龄较小 (<24个月) 和较高的峰值维加巴特林剂量是显著的风险因素.
- 限制DWI扩散是常见的,特别是在pons (100%的DWI变化病例).
- 在最初的MRI报告中,VABAM往往未被充分识别或误诊 (仅有20.6%正确识别).
结论:
- VABAM在患有ES的儿童中普遍存在,特别是在2岁以下和服用较高维加巴林剂量的儿童中.
- VABAM通常是可逆的,在临床上是无声的,这凸显了需要提高认识的必要性.
- 临床医生和放射科医生的更好地识别VABAM对于更安全的vigabatrin使用和预防误诊至关重要.
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