在体外评估水凝线圈与液体栓塞和硬化剂相结合,用于内血管栓塞
Akiko Narita1, Hiroaki Okada2, Yuki Maruchi2
1Department of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, Japan. narita.akiko.046@mail.aichi-med-u.ac.jp.
Cardiovascular and interventional radiology
|June 17, 2025
概括
硬化剂可以损坏水凝线圈,可能导致无效的栓塞. 这项研究发现,乙醇胺酸盐和波利多卡诺尔导致水凝线圈破裂,而n-丁-2-烯酸盐则导致纹.
科学领域:
- 干预性放射学 干预性放射学
- 生物材料科学 生物材料科学
- 血管栓塞是因为血管栓塞.
背景情况:
- 水凝线圈用于栓塞,有时使用液体剂.
- 它们与这些代理物的相互作用需要评估.
研究的目的:
- 评估液体栓塞和硬化剂对水凝线圈的影响.
- 了解潜在的不良临床结果.
主要方法:
- 水凝卷被浸泡在乙醇,n-丁-2-烯酸 (NBCA),乙醇胺酸与iopamidol (EOI) 和polidocanol中.
- 在酸盐缓冲盐水中预浸泡后,通过显微镜观察到线圈变化.
主要成果:
- 乙醇和NBCA并没有改变线圈直径;NBCA导致表面脱光.
- 氧化和聚多卡诺尔增加了线圈直径,但导致了水凝裂纹.
- 在暴露剂之前预先浸泡在盐水中也导致了EOI和polidocanol的裂.
结论:
- 硬化剂可以损坏或使水凝线圈失效.
- 结合这些药物可能导致不充分或非目标栓塞.
- 临床使用需要仔细考虑这些相互作用.
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