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怀孕期间母亲吸入电子烟的暴露:对益生素和丁氧化酶的影响

Julie A Griffith^1,2, Kallie J Schafner^1,2, Krista L Garner^1,2

¹Department of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.

Cardiovascular toxicology

|June 17, 2025

概括

孕妇在怀孕期间接触电子烟 (e-cig) 会减少胎儿和胎盘的生长. 这种电子烟暴露也导致了荷尔蒙失衡和增加了胎盘氧化应激,影响胎儿发育.

科学领域:

生殖毒理学生殖毒理学
发育生物学是发展生物学.
内分泌学在内分泌学.

背景情况:

怀孕涉及对胎儿发育至关重要的代谢和内分泌调整.
由于这些生理变化的中断,对母亲和胎儿健康的不良影响可能会产生.
关于怀孕期间接触电子烟 (e-cig) 的影响的研究有限.

研究的目的:

在大鼠模型中研究母亲电子烟气溶暴露对荷尔蒙平衡,氧化还原状态和胎儿发育的影响.
为了确定在怀孕期间接触电子烟是否会导致母体及其胎儿的不良结果.

主要方法:

怀孕的斯普拉格-道利大鼠从妊娠第10天到第19天暴露在电子烟气溶或过空气中.
在妊娠第20天收集了血清,肝脏,肺部,卵巢和胎盘组织进行分析.
评估了胎儿和胎盘的质量,性别比,胎盘的丁氧化酶 (XO) 活性和循环中的益生菌素 (PRL) 水平.

主要成果:

与对照组相比,电子烟暴露显著减少了胎儿和胎盘质量.
在暴露于电子烟的组中,胎盘的丁氧化酶 (XO) 活性显著升高.
暴露于电子烟气溶的母乳中,循环中的益乳素 (PRL) 水平显著降低.

结论:

在怀孕期间母亲吸入电子烟会对胎儿生长产生负面影响.
胎盘XO活性增加和PRL水平降低表明潜在的氧化还原和荷尔蒙失衡.
这些不平衡可能导致胎儿生长减缓,并可能影响长期发育.

关键词:

电子烟是电子烟的产品.孕期孕期孕期孕产腺素是什么? 孕产腺素是什么?亚丁氧化酶是一种丁氧化酶.

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