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提高慢性病诊断和管理的准确性:临床标记物的参考材料和参考测量程序
Hwee Tong Tan1, Qinde Liu1, Tang Lin Teo1
1Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore, Singapore.
Annals of laboratory medicine
|June 18, 2025
概括
精确测量慢性病 (CKD) 生物标志物对于早期检测和管理至关重要. 建立参考材料 (RMs) 和参考测量程序 (RMP) 确保了对CKD的可靠诊断测试.
科学领域:
- 临床诊断 临床诊断 临床诊断
- 生物标志物的标准化标准化.
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 影响全球超过10%的人口,造成严重的死亡风险.
- 糖尿病,肥胖和高血压的患病率越来越高,加剧了CKD的临床和经济负担.
- 准确的临床实验室检测CKD生物标志物对于早期检测,治疗和监测至关重要.
研究的目的:
- 突出参考材料 (RM) 和参考测量程序 (RMP) 在标准化CKD生物标志物测量的关键作用.
- 强调RMS和RMP对于准确的体外诊断测试的重要性.
- 倡导为关键CKD标志物建立RM和RMP.
主要方法:
- 审查参考材料 (RMs) 和参考测量程序 (RMP) 的重要性.
- 专注于对关键CKD生物标志物的标准化:尿液和血清肌素,尿液白蛋白,血清囊素C和尿素.
- 讨论标准化如何支持可靠的诊断实践.
主要成果:
- 通过实施RM和RMP,可以实现CKD生物标志物的标准化测量.
- 准确的诊断实践是缓解CKD日益增长的全球医疗保健挑战的基础.
- 可靠的CKD标志物的测量对于有效的疾病管理至关重要.
结论:
- 建立RM和RMP对于标准化CKD生物标志物测量至关重要.
- 通过RM和RMP的标准化确保了准确的体外诊断,有助于CKD管理.
- 实施标准化测量实践将支持全球努力减少CKD发病率和相关医疗保健成本.
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