D-Tagatose通过抑制炎症,减少肠道屏障损伤和调节肠道菌群组成来减轻DSS诱导的性结肠炎
Le Wang1, Houzhen Lu1, Haitao Gui1
1School of Biological Engineering, Institute of Biomass Science and Engineering, Henan University of Technology, 450001, Zhengzhou, China. wanglely1984@163.com.
Food & function
|June 18, 2025
概括
D-tagatose通过减少炎症和恢复肠道健康,有效治疗性结肠炎 (UC). 这种功能性食物对预防和管理这种炎症性肠病 (IBD) 充满希望.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 性结肠炎 (UC) 是一种炎症性肠病 (IBD),对全球健康构成重大挑战.
- 目前对UC的治疗策略往往存在局限性,需要探索新的干预措施.
研究的目的:
- 在小鼠模型中研究D-塔加对硫酸 (DSS) 诱导的大肠炎的保护作用.
- 阐明D-塔加在结肠炎中发挥治疗作用的潜在机制.
主要方法:
- 组织病理学分析 (H&E,AB-PAS染色).
- 免疫光和免疫组织化学用于蛋白质表达.
- 生物化学测试 (ELISA,qPCR,西式斑点) 检测炎症标志物和细胞因子.
- 评估肠道微生物群组成和短链脂肪酸 (SCFA) 生产.
主要成果:
- 服用D-塔加可显著改善结肠炎的症状,包括体重增加,结肠长度增加,疾病活动指数 (DAI) 降低和组织病理学评分.
- D-塔加抑制了关键的炎症媒介,如髓氧化酶 (MPO),INOS,COX-2和促炎细胞因子 (TNF-α,IL-1β,IL-6),同时增加了抗炎性IL-10.
- 该疗法通过上调紧密结蛋白 (ZO-1,Occludin) 和粘素 (MUC-2),调节肠道微生物群失调,并增加SCFA水平来增强肠道屏障完整性.
结论:
- D-塔加在减弱DSS诱导的UC方面显示出显著的治疗潜力.
- 它的有效性归因于对炎症性细胞因子的调节,恢复肠道屏障功能,维持肠道微生物群的稳定性,并增强SCFA生产.
- D-塔加是UC预防和治疗的安全有效的功能性食品策略.
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