前列腺癌负担的全球流行病学趋势:2021年全球疾病负担研究的综合分析
1Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Translational andrology and urology
|June 18, 2025
概括
全球前列腺癌 (PC) 发病率已升超过160%,患病率上升但死亡率下降. 这种日益增长的负担凸显了地区和年龄相关的巨大差异,需要有针对性的预防和管理策略.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 前列腺癌 (PC) 在全球健康方面存在显著差异.
- 目前的选方法面临着关于实用性和成本效益的辩论.
- 了解长期趋势和社会人口统计学影响对于有效控制至关重要.
研究的目的:
- 调查从1990年到2021年的全球PC发病率,死亡率,流行率和残疾调整寿命年 (DALYs).
- 分析PC负担的时间和区域趋势.
- 为了告知有针对性的预防和资源分配战略.
主要方法:
- 利用的全球疾病负担 (GBD) 研究2021年PC指标 (1990-2021) 的数据.
- 使用百分比变化和估计年百分比变化 (EAPC) 评估时间趋势.
- 使用Pearson相关性和Joinpoint回归来分析趋势和社会人口指数 (SDI) 关系.
主要成果:
- 全球PC发病率增加了161.53%;流行率上升了0.568%;死亡率下降了0.83%.
- 东欧和南亚的疾病负担较高;PC主要影响70岁以上的个人.
- 较高的SDI与PC患病率的增加相关,但与DALYs的关联较弱;高收入地区存在差异.
结论:
- 前列腺癌代表着一个日益增长的全球健康挑战,具有显著的区域和年龄相关的差异.
- 虽然较高的SDI与患病率的增加有关,但仅仅获得医疗保健并不能消除疾病负担.
- 集成早期检测,公平待遇和长期管理的有针对性的战略对于减少差异和改善结果至关重要.
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