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Updated: Sep 19, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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在GluN2A选择性负基调节器的结构基础上的进展

Yinlong Li1, Hongjie Yuan2, Steven H Liang1

  • 1Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.

ACS medicinal chemistry letters
|June 18, 2025
PubMed
概括

N-甲基-D-酸盐受体 (NMDARs) 对大脑功能至关重要. 用特定调节剂向GluN1/GluN2A NMDAR显示出治疗神经系统疾病的前景.

关键词:
中枢神经系统 (CNS) 的疾病.在GluN2A子单元中.没有NMDAR的药物.负基调制剂 (NAMs) 是一种负基调制剂.结构与活动关系 (SAR)

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