在急性损伤中,D-二次体与住院死亡风险之间的关联基于潜在类动态轨迹
Lixiang Rao1, Jiazheng Sun2, Xingyang Zhao3
1Division of Nephrology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in medicine
|June 18, 2025
概括
在急性损伤 (AKI) 的住院患者中,D-二次体水平显示了两个不同的模式. 在D-二次体下降之后的早期峰值表明住院死亡的风险更高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
背景情况:
- 急性损伤 (AKI) 是住院患者的常见和严重疾病.
- 凝血激活的标志物D-二聚体可能在AKI预后中起作用.
- 了解D-二次体动态对于AKI中的风险分层至关重要.
研究的目的:
- 在住院的AKI患者中识别不同的纵向D-二次体轨迹.
- 分析这些D-二次体模式与住院死亡风险之间的关联.
主要方法:
- 在AKI患者的回顾性研究中,在发病后30天内至少测定了三次D-二次体.
- 隐性类轨迹建模 (LCTM) 来识别D-二次元模式.
- 后勤回归和卡普兰-梅尔生存分析以评估死亡风险.
主要成果:
- 确定了两个不同的D-二次体轨迹:早期峰值与逐渐下降和持续的低水平稳定性.
- 早期峰值衰退组显示,住院死亡率的风险显著增加 (OR 2.27).
- 在高峰衰退组中观察到医院生存率降低,独立于并发症.
结论:
- 在AKI发作后,D-二元体表现出两个特征性的纵向动态轨迹.
- 早期峰值之后的D-二聚合物下降与AKI患者的住院死亡率增加和生存率降低有关.
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