肌肉内脂肪分布的年龄相关差异:在人类脚脚下 flexors 的空间量化
Zhenkai Zhao1,2, Fiona Elizabeth Smith2,3, Taylor J M Dick4
1Department of Life Sciences, Manchester Metropolitan University, Manchester, United Kingdom.
Frontiers in bioengineering and biotechnology
|June 18, 2025
概括
老年人显示腿部肌肉内肌肉脂肪聚集增加,表明脂肪分布更密集. 这项研究为追踪肌肉健康和脂肪替代提供了新的途径.
科学领域:
- 生物医学工程 生物医学工程
- 放射学 放射学是指放射学
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 肌肉内脂肪 (IMF) 积累是骨肌肉健康的关键指标.
- 目前的方法报告了肌肉内脂肪分数 (FF) 的平均值,但缺乏空间分布分析.
- 了解国际货币基金组织的空间分布对于准确的肌肉健康评估至关重要.
研究的目的:
- 评估肌肉内FF分布的2D和3D空间特征.
- 研究特定腿部肌肉 (MG,LG,SOL) 内肌肉内FF集群的年龄相关差异.
- 开发用于量化肌内FF空间分布的新方法.
主要方法:
- 招募了32名身体活跃的年轻人和老年人.
- 从mDixon MRIs中提取肌肉内FF区域,使用区域生长方法.
- 量化3D肌内FF集群和密度使用Delaunay模块化和里普利函数.
主要成果:
- 与年轻人相比,老年人在所有测量的肌肉中表现出明显更密集的肌内FF聚类.
- 老年人中的Delaunay平均边长较短,表明聚类增加.
- 里普利的K函数分析证实了老年人中更大的FF聚类;衰老是一个重要的因素,但性别不是.
结论:
- 本研究为表征肌内FF空间分布建立了一个客观的框架.
- 开发的方法允许跟踪骨肌肉脂肪替代.
- 为评估骨肌肉健康提供更强大和更敏感的标记物.
相关概念视频
01:02Hypodermis
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
01:28Muscles of the Leg that Move the Foot and Toes
The human leg comprises an intricate system of muscles that facilitate the movement of feet and toes. Within this system, the muscles are categorized into the anterior, lateral, and posterior compartments, each with a unique set of muscles carrying out specific functions.
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles.
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles.