为治疗阿片类药物使用障碍而接受延长释放布普伦诺芬的患者的疼痛管理策略:一个范围审查
Pouya Azar1,2, Jane J Kim1,2, Farbod Azarmju1
1Complex Pain and Addiction Service, Vancouver General Hospital, Vancouver, BC, Canada.
Substance use : research and treatment
|June 18, 2025
概括
在服用延长释放布伦诺芬 (BUP-XR) 的阿片类药物使用障碍 (OUD) 患者的疼痛管理具有挑战性. 目前的证据表明多式联运方法,但缺乏高质量的指导方针.
科学领域:
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
- 成 药物 药物 药物 药物
背景情况:
- 患有阿片类药物使用障碍 (OUD) 的患者的疼痛管理复杂.
- 延长释放布伦诺芬 (BUP-XR) 用于OUD治疗,但这些患者的疼痛管理策略尚未明确定义.
- 对于OUD患者的疼痛,存在各种各样的有争议的治疗策略.
研究的目的:
- 描述和评估药理性疼痛管理策略,用于治疗OUD的BUP-XR患者.
- 综合当前关于治疗OUD用BUP-XR治疗患者疼痛的证据.
主要方法:
- 从多个数据库 (Ovid Medline,EMBASE,CINAHL,Web of Science,PsycInfo) 的文献进行范围审查,截至2025年2月.
- 包括讨论在接受BUP-XR.R.治疗的患者中治疗急性或慢性疼痛的文章.
- 提取关于疼痛严重程度,功能,患者满意度和不良事件的数据;研究的独立质量评级.
主要成果:
- 从980篇的初步搜索中,只有6篇文章符合纳入标准,这表明整体证据强度不佳.
- 大多数研究使用了BUP-XR与其他止痛药 (阿片类药物,非阿片类药物,NSAIDs) 结合的延续或转换为语言下布诺芬.
- 在大多数情况下,可以达到足够的疼痛控制,没有观察到呼吸抑制或毒性.
结论:
- 目前,对于BUP-XR治疗患者的疼痛管理缺乏明确的指导方针.
- 临床医生倾向于采用结合阿片类药物,非阿片类止痛药和区域麻醉的多式止痛方法.
- 需要进一步进行高质量的研究,包括随机对照试验,以建立最佳的疼痛管理策略.
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