固体器官移植接受者的骨质疏松症治疗:一种基于器官的方法
Soumya Kurnool1, Nandi Shah2, Preethika Ekanayake2,3
1Division of Endocrinology, Diabetes and Metabolism, University of California, 4168 Front Street, San Diego, CA 92103, USA Department of Endocrinology, Diabetes and Metabolism, Veterans' Affairs, La Jolla, CA, USA.
Therapeutic advances in endocrinology and metabolism
|June 18, 2025
概括
固体器官移植接受者面临骨质疏松症和骨折的高风险. 建议早期使用双酸盐治疗,以控制这些患者的骨密度下降.
科学领域:
- 腎科和移植醫學 腎科和移植醫學
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 骨和矿物质疾病在固体器官移植接受者中很常见.
- 移植前和移植后的因素有助于高骨质疏松症和骨折风险.
研究的目的:
- 审查固体器官移植接受者骨质疏松症的治疗选择.
- 讨论移植后管理骨密度损失的挑战.
主要方法:
- 关于骨质疏松症管理策略的文献综述.
- 对维生素D,,双酸盐,登苏马布和骨代谢剂的治疗疗效的分析.
主要成果:
- 低的移植前骨密度预测了移植后骨折风险.
- 移植后6-12个月内发生显著的骨密度损失.
- 双酸盐对患者有益的证据最多.
结论:
- 早期的双酸盐干预对于治疗移植患者的骨质疏松症至关重要.
- 需要全面的管理策略来解决骨密度下降的问题.
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