尿酸与高密度脂蛋白的比率增加与中风风险正相关
Tieshi Zhu1, Yong He2, Erxinxian Bei1,3
1Department of Neurology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China.
Frontiers in neurology
|June 18, 2025
概括
尿酸与HDL比率 (UHR) 与较高的中风风险有关. 这项研究发现UHR和中风之间存在显著的正相关性,强调其作为预测标记物的潜力.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 神经学 神经学
背景情况:
- 尿酸与HDL比率 (UHR) 是一种与高血压和糖尿病相关的新型指数.
- 以前的研究将UHR与缺血性心脏病和冠状动脉功能联系起来.
- 有限的研究已经探索了UHR和中风风险之间的关联.
研究的目的:
- 调查UHR与中风风险之间的关系.
- 评估UHR和中风发病率之间的非线性关联.
- 为了确定UHR是否可以作为中风的预测标记.
主要方法:
- 分析了NHANES 1999-2023数据库中33192个人的数据.
- 利用受限立方线 (RCS) 分析来评估非线性关系.
- 使用后勤回归来评估UHR作为连续变量和四分位数.
主要成果:
- UHR显示与中风风险有显著的积极关联 (OR=1.02,95% CI 1.01-1.03).
- 在UHR的最高四分之一的个体中,中风风险增加了31% (OR=1.31,95% CI 1.11-1.55).
- 这种关联是线性的,而不是非线性的 (p为非线性=0.65).
结论:
- 在UHR和中风风险之间存在显著的正相关性.
- 升高的UHR水平与患中风的可能性增加有关.
- UHR可能是评估中风风险的有价值生物标志物.
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