恶性肺溢是非小细胞肺癌免疫治疗结果的负预后因素:单中心回顾性研究
Jing Wang1, Boyue Pang1, Jiali Zhang1
1Key Laboratory of Cancer Immunology and Biotherapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Journal of thoracic disease
|June 18, 2025
概括
在接受免疫治疗的非小细胞肺癌 (NSCLC) 患者中,恶性肺 (MPE) 与更差的生存结果有关. 即使使用免疫检查点抑制剂,MPE也是预后不佳的独立风险因素.
科学领域:
- 在瘤学瘤学.
- 胸部瘤学 胸部瘤学
- 癌症转移 癌症转移
背景情况:
- 恶性流 (MPE) 是非小细胞肺癌 (NSCLC) 的常见转移部位.
- 在NSCLC中MPE的存在与预后不佳相关.
- 在接受免疫治疗的患者中,MPE结局的数据有限.
研究的目的:
- 为了评估接受免疫治疗的MPENSCLC患者的临床结果.
- 评估MPE对接受免疫检查点抑制剂 (ICI) 治疗的NSCLC患者的存活率的影响.
主要方法:
- 对167名接受ICI治疗的NSCLC患者进行了回顾性研究.
- 患者被分为MPE (n=84) 和对照组 (没有流,n=83).
- 主要终点包括整体存活率 (OS) 和无进展生存率 (PFS).
主要成果:
- 与对照组相比,患有MPE的NSCLC患者的PFS和OS明显较短 (P<0.05).
- 在MPE组中,PFS的中位数为9.50个月,在对照组中为16.50个月.
- 在MPE组中,中位寿命为20.0个月,在对照组中为32.0个月.
结论:
- 恶性性流是NSCLC预后不佳的独立风险因素.
- 这种不良预后甚至在接受免疫疗法治疗的患者中仍然存在.
相关概念视频
01:28Pleural Effusion II: Symptoms and Management
277
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
277
01:25Pleural Effusion I: Introduction
1.9K
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
1.9K
01:27Tumor Immunotherapy
675
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
675