部分与全乳房辐射的财务毒性:系统性审查
Taema Brinjikji1, Kimberly S Corbin1,2, Zhen Wang1
1Evidence-Based Practice Center, Mayo Clinic, Rochester, MN.
Mayo Clinic proceedings. Innovations, quality & outcomes
|June 18, 2025
概括
加速部分乳房照射 (APBI) 与全乳房照射 (WBI) 相比,导致财务毒性较低. 这可能是由于APBI的治疗时间更短,降低了成本和离职时间.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 辐射疗法 辐射疗法
背景情况:
- 对于癌症患者来说,财务毒性是一个重大问题,包括自付费用,旅行费用和收入损失.
- 全乳房照射 (WBI) 是早期乳腺癌的标准治疗方法,但其更长的持续时间可能会导致财务负担.
- 加快部分乳房照射 (APBI) 提供更短的治疗过程,可能减轻财务毒性.
研究的目的:
- 为了比较与加速部分乳房照射 (APBI) 与全乳房照射 (WBI) 相关的财务毒性.
- 评估不同乳腺癌辐射治疗方式对患者的经济影响.
主要方法:
- 进行了随机临床试验和观察性研究的系统审查.
- 在2024年4月之前发表的研究是有资格的,如果它们评估了在接受APBI或WBI的早期乳腺癌成年女性的金融毒性.
- 独立审查员选择了9项符合纳入标准的研究.
主要成果:
- 四项研究表明,与APBI相比,WBI的财务困难更大,在治疗后3个月和1-2年内发现了差异.
- 专注于旅行费用和工作缺勤的四项研究报告说,APBI的财务影响较低.
- 一项使用综合金融毒性评分的研究发现,APBI和WBI之间没有显著差异.
结论:
- 加快部分乳房照射 (APBI) 与全乳房照射 (WBI) 相比,与降低的财务毒性有关.
- 由于APBI的治疗时间较短,这可能是导致APBI对患者的经济负担较低的一个因素.
- APBI可能代表了早期乳腺癌更具经济可持续性的治疗选择.
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