豆对肠道微生物群和免疫反应的调节减轻了因虹素诱导的肠道毒性
1Department of Handan First Hospital, Handan, China.
豆 (SPs) 通过恢复肠道屏障功能和有益的肠道细菌,减轻易诺托坎诱导的腹和肠道损伤. 医疗专家在治疗化疗相关的胃肠道毒性方面表现有前途.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 氨酸 (CPT-11) 对于治疗结直肠和胰腺癌至关重要,但会导致严重的胃肠道毒性,特别是腹.
- 这种毒性限制了治疗的坚持,并影响了患者的生活质量.
- 豆 (SPs) 具有抗炎和益生菌特性,可能增强肠道屏障功能.
研究的目的:
- 为了研究大豆 (SPs) 保护性作用,以防止伊利诺特干诱导的肠损伤.
- 探索SPs的机制,包括微生物群调节,免疫调节和粘膜修复.
主要方法:
- 雌性C57BL/6小鼠被分配到对照组,Irinotekan组,Pre-SPs+Irinotekan组或SPs+Irinotekan组.
- 评估了腹,体重,肠道组织学 (H&E),屏障完整性 (WB,IHC),血清细胞因子 (TNF-α,IL-6通过ELISA),中性粒细胞透 (流细胞计) 和便微生物群 (16SrRNA测序).
主要成果:
- SPs显著降低了腹发病率和体重减轻 (P < 0.05).
- 组织学显示,SP恢复了肠道结构,改善了屏障完整性 (occludin,ZO-1),并降低了透性 (P<0.05).
- 此外,SPs还能使氨酸诱导的肠道失调正常化,增加有益细菌 (Lactobacillus,Bifidobacterium) 和减少促炎细胞因子 (TNF-α,IL-6) 和中性粒细胞透 (P <0.05).
结论:
- 豆可以提供保护,免受伊利诺特干诱导的肠道毒性.
- 机制包括微生物群调节,免疫调节和肠道屏障恢复.
- SPs代表了一种潜在的治疗策略,用于管理化疗引起的肠损伤.
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