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细胞外囊泡在癌症中的治疗应用的当前趋势

Yazan Almasry¹, Fayrouz Mustafa¹, Mohammed Alfuwais¹

¹College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Frontiers in oncology

|June 18, 2025

概括

细胞外囊泡 (EVs) 显示出早期癌症检测和个性化治疗的前景. 这些生物标志物具有高灵敏度和特异性,为先进的癌症诊断和治疗铺平了道路.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
分子生物学分子生物学

背景情况:

细胞外囊泡 (EVs) 在癌症生物学中至关重要,影响瘤生长,转移和瘤微环境.
它们独特的分子构成使得电动汽车在癌症诊断和向治疗方面具有价值.

研究的目的:

审查细胞外囊泡 (EVs) 在癌症诊断和治疗中的作用.
评估EV衍生生物标志物的诊断性能和治疗疗效.

主要方法:

使用PubMed,Scopus和Web of Science进行了系统的文献搜索.
关键词包括"细胞外膀"",癌症治疗"",生物标志物"",外体"",瘤微环境"和"精密医学".
包括298篇文章,重点关注EV隔离,表征,诊断准确性和治疗应用.

主要成果:

来自EV的生物标志物在各种癌症中表现出高的诊断性能.
具体的例子包括用于乳腺癌的miRNA EVs (98%的灵敏度,96%的特异性) 和用于肝细胞癌的EV-RNA (93.8%的灵敏度,74.5%的特异性).
电动汽车作为有效的药物输送系统,提高化疗和免疫疗法的精度,同时降低毒性.

结论:

由于其高灵敏度和特异性,EV疗法为早期癌症检测和个性化治疗提供了显著的潜力.
标准化EV隔离和表征协议对于瘤学的临床转化至关重要.

关键词:

生物标志物生物标志物癌症治疗疗法癌症治疗外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.精准医学是一门精准医学.瘤微环境是一个微环境.

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