来自中国云南山羊的Akabane病毒田间隔离物中的遗传多样性和变异
Jinping Wang1, Aiguo Xin1, Yuwen He1
1Yunnan Tropical and Subtropical Animal Virus Disease Laboratory, Yunnan Academy of Animal Husbandry and Veterinary Science, Kunming, China.
Frontiers in veterinary science
|June 18, 2025
概括
阿卡班病毒 (AKAV) 对孕山羊构成风险,导致流产和出生缺陷. 这项研究揭示了中国云南地区广泛的AKAV感染,Ia和新兴的基因型II菌株被确定,突出了控制策略的必要性.
科学领域:
- 兽医病毒学 兽医病毒学
- 关节动物传播的病毒
- 动物传染性疾病 动物传染性疾病
背景情况:
- 阿卡班病毒 (AKAV) 是昆虫传播的病原体,属于*Peribunyaviridae*家族,已知会导致反动物的大量生殖损失.
- 关于AKAV流行率和基因多样性的数据有限,特别是在中国的山羊种群中.
- 由于潜在的经济影响和疾病传播风险,了解山羊中的AKAV至关重要.
研究的目的:
- 在中国云南省的山羊中调查Akabane病毒 (AKAV) 的基因型特征和血清流行率.
- 分析山羊衍生 AKAV 菌株的遗传多样性和进化模式.
- 为该地区针对AKAV制定有针对性的预防和控制措施提供信息.
主要方法:
- 采集四年 (2019-2023) 的山羊血液样本,用于例行疾病监测.
- 血清学评估以确定云南山羊群中AKAV血清流行率.
- 五个孤立的AKAV菌株的全基因组测序,用于遗传学和进化分析.
主要成果:
- 在云南山羊中检测到AKAV的显著血清流行率,总体达到7.69%,在某些地区高达27.8%.
- 遗传学分析将分离的菌株分为Ia和Ib基因组,其中Ia占主导地位.
- 在中国发现了基因型II菌株的出现 (例如,TJ2016,CQ-AKAV-1-2023),这表明病毒动态正在演变.
结论:
- 云南省的山羊受到阿卡班病毒的广泛影响,需要紧急关注.
- 羊中AKAV的遗传场景包括已建立的Ia/Ib基因组和新兴的基因型II菌株.
- 有效的预防和控制策略对于减轻AKAV对中国山羊健康和生产力的影响至关重要.
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