微型/纳米机器人在抗微生物治疗中:应对抗生素耐药性的挑战
Xutong Chen1,2, Yong Li3,4, Chunhua Wang5
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Materials today. Bio
|June 18, 2025
概括
抗菌微型和纳米机器人 (MNRs) 对抗药物耐药生物膜有希望. 本次审查强调了用于细菌根除和生物膜破坏的MNR策略,同时指出了临床使用的挑战.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药性是全球主要的健康威胁.
- 细菌生物膜显著增加了对传统治疗的耐药性.
- 生物膜感染很难治疗,并且经常复发.
研究的目的:
- 审查抗微生物微型和纳米机器人 (MNR) 治疗的最新进展.
- 通过使用MNRs强调用于细菌根除和生物膜破坏的创新策略.
- 为应对MNR临床翻译的挑战和未来方向.
主要方法:
- 对抗微生物微型和纳米机器人的当前文献的综述.
- 分析MNR在准和透生物膜方面的能力.
- 对克服耐药性和提高治疗疗效的策略的评估.
主要成果:
- 抗微生物药物治疗中,MNRs提供了增强的运动性,向性和透性.
- 针对生物膜破坏,正在开发各种创新的MNR设计和策略.
- 在生物相容性,成像和临床翻译方面仍然存在重大挑战.
结论:
- 抗生素耐药性细菌生物膜在抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素耐药性抗生素
- 需要进一步的研究来解决成功临床应用的技术障碍.
- 随着MNR技术的发展,它有可能彻底改变治疗持久性感染的方法.
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