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老年人认知功能和肌肉质量之间的关系:基于CLHLS的纵向研究
Yin Shi1,2, Yu Zhang2, Xinyu Yang2
1Department of Critical Care Medicine, Deqing People's Hospital, Huzhou, Zhejiang, China.
Frontiers in psychiatry
|June 18, 2025
概括
保持足够的肌肉质量对于老年人的认知健康至关重要. 更高的尾骨肌指数 (ASMI) 预测了更好的认知功能,可能有助于预防痴呆症.
科学领域:
- 老年学和衰老研究研究.
- 神经科学与认知健康
- 肌肉骨健康和萨科佩尼亚
背景情况:
- 萨科佩尼亚是老龄化人口中残疾和死亡的主要原因.
- 认知功能和肌肉质量之间的复杂关系,以及潜在的机制,仍然不完全理解.
- 研究这种联系对于制定支持健康衰老的战略至关重要.
研究的目的:
- 为了检查认知功能和老年人肌肉质量之间的纵向关系.
- 为了确定肌肉质量对认知轨迹的潜在预测效应.
- 为了建立特定性别的肌肉质量值,可以减轻认知能力下降.
主要方法:
- 来自中国长度健康长寿调查 (CLHLS) (2011-2018) 的2536名年龄≥60岁的参与者的分析.
- 利用交叉滞后模型和受限立方线来进行统计分析.
- 使用SPSS,MPLUS和R软件进行数据选和建模.
主要成果:
- 在所有测量点上,认知功能与肌肉质量呈正相关性.
- 尾骨肌指数 (ASMI) 显著预测了迷你精神状态检查 (MMSE) 随着时间的推移,特别是女性的得分.
- 在骨肌量和认知障碍之间观察到非线性增长趋势,这表明最佳的ASMI值 (男性7.45kg/m2,女性5.68kg/m2).
结论:
- 肌肉质量显著预测认知轨迹,女性有明显的影响.
- 保持ASMI高于已确定的性别特定值可能是减缓认知衰退的关键策略.
- 肌肉质量作为痴呆症预防的可修改生物标志物,需要在不同人群中进一步验证.
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