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与vedolizumab相关的肝毒性:一个患有性结肠炎的患者的病例报告
Nathalia I Crosewski1, Aryadne H M Pereira, Luiz R Kotze
1Gastroenterology Department, Complexo Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
European journal of gastroenterology & hepatology
|June 18, 2025
概括
维多利祖马布用于炎症性肠道疾病,很少会导致肝损伤. 这一案例突出了药物诱导的肝损伤,强调了需要监测肝功能在vedolizumab治疗期间.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 维多利祖马布是一种针对炎症性肠病的抗整氨酸α4β7单克隆抗体.
- 虽然通常是安全的,但有报道罕见的vedolizumab相关的肝毒性病例.
- 肝毒性可以表现为胆固醇,混合或肝细胞损伤.
研究的目的:
- 在患有性结肠炎的患者中报告vedolizumab诱导的肝损伤病例.
- 描述这种不良事件的临床,生化和组织学特征.
- 强调监测肝检测的重要性,并区分药物诱导的肝损伤与其他肝病变.
主要方法:
- 一个病例报告,一个患有性结肠炎的病人接受了vedolizumab治疗.
- 进行了临床评估,肝功能测试,肝脏成像和肝脏活检.
- 对组织学发现的分析和患者对停止使用维多利祖马布的反应.
主要成果:
- 患者在开始服用vedolizumab后发生胆固醇性肝损伤.
- 肝活检揭示了淋巴细胞透物,淋巴细胞聚合物,乙素,血细胞和接口活动.
- 停止使用维多利祖马布导致肝脏检测的逐渐改善.
结论:
- 维多利祖马布可以导致肝损伤,呈现为胆固醇或混合模式.
- 肝活检结果支持了药物诱导的肝损伤的诊断.
- 在接受vedolizumab的患者中,密切监测肝功能至关重要,以检测和管理潜在的肝毒性.
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