桑托胡摩尔通过调节肠道微生物代谢物来缓解与炎症性肠病相关的骨质疏松症
Weiqing Fan1,2, Tianshuang Xia1, Yiping Jiang1
1School of Pharmacy, Naval Medical University, Shanghai, China.
Phytotherapy research : PTR
|June 18, 2025
概括
蜂中的桑托胡醇 (XAN) 通过改善肠道微生物群和减少炎症,有效治疗与炎症性肠道疾病 (IBD) 相关的骨质疏松症. 这种天然化合物保护肠道屏障,并促进IBD患者的骨健康.
科学领域:
- 药理学和胃肠病学 药理学和胃肠病学
- 骨代谢和微生物组研究研究
背景情况:
- 炎症性肠病 (IBD) 通常导致骨质疏松症 (OP) 由于慢性炎症,营养不良和皮质类固醇使用.
- 目前对IBD相关的OP有效的药理疗法有限.
- 黄醇 (XAN) 是一种来自蜂的黄类化合物,具有抗炎症和抗骨质疏松作用的潜力.
研究的目的:
- 为了研究香醇 (XAN) 对炎症性肠病 (IBD) 相关骨质疏松症 (OP) 的治疗作用.
- 探索XAN作用的潜在机制,重点关注其对肠道微生物群的调节.
- 在IBD相关的OP模型中评估XAN对肠道屏障功能,炎症和骨代谢的影响.
主要方法:
- 一个与炎症性肠病 (IBD) 相关的骨质疏松症 (OP) 鼠标模型是使用硫酸 (DSS) 建立的.
- 通过疾病活性指数 (DAI) 评分,结肠病理学和粘膜屏障评估来评估香醇 (XAN) 的治疗效果.
- 使用血清炎症因子,骨周转标记物和股骨微型CT扫描分析了骨代谢;通过16SrDNA测序和代谢学研究了肠道微生物群的变化.
主要成果:
- 桑托胡醇 (XAN) 显著缓解了结肠炎症,保护了肠道粘膜屏障,并降低了DSS诱导的小鼠的疾病活性.
- 通过减少促炎性细胞因子 (IL-6,IL-17A,TNF-α),降低骨再吸收标记CTX-I,增加骨形成标记OPG,XAN表现出抗骨质疏松作用.
- 肠道微生物群分析显示,XAN增加了微生物多样性,并改变了特定的细菌丰度,特别是调节了托 (Trp) 代谢途径,这与改善的肠道屏障和骨健康有关.
结论:
- 桑托胡摩尔 (XAN) 有效地改善与炎症性肠病 (IBD) 相关的结肠损伤和骨损失.
- 通过调节肠道微生物群的组成和功能,XAN发挥其治疗作用,特别是针对托 (Trp) 代谢途径.
- 通过保护肠道屏障的完整性和通过肠道微生物群干预促进骨形成,XAN为IBD相关的骨质疏松症提供了一个有前途的治疗策略.
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