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盖莱克和糖尿病视网膜病变的因果关联:一个双样本的孟德尔随机化研究

Shanshan Yang¹, Cong Zheng¹, Qianyin Zheng¹

¹Department of Ophthalmology, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, China.

Current eye research

|June 18, 2025

概括

这项研究表明,较高的加勒-4 (Gal-4) 水平增加了糖尿病视网膜病变 (DR) 和扩散性DR (PDR) 的风险. 加勒-3 (Gal-3) 和加勒-3结合蛋白与严重非增殖性DR (SNPDR) 有关,而加勒-9 (Gal-9) 显示风险降低.

科学领域:

遗传学和眼科医学
生物标志物和疾病风险
门德尔的随机化研究研究.

背景情况:

糖尿病视网膜病变 (DR) 是糖尿病的一个显著的微血管并发症,影响视力.
观察性研究表明,加勒素 (Gal) 与DR风险之间存在关联,但因果关系仍然不确定.
对于有针对性的干预措施来说,了解特定的盖莱克和DR表型之间的因果关系至关重要.

研究的目的:

调查循环中的加列家族水平与糖尿病视网膜病变 (DR) 风险之间的因果关系.
探索甲状腺素和特定的DR表型之间的因果关系:增殖DR (PDR),背景DR (BDR) 和严重的非增殖背景DR (SNPDR).
采用双样本门德尔随机化 (MR) 分析来进行强大的因果推断.

主要方法:

从全基因组关联研究 (GWAS) 中利用单核酸多态 (SNP) 作为仪器变量 (IV).
通过严格的选过程,通过严格的选过程,选择了与 galectins 相关的合格 SNP.
执行孟德尔随机化分析,主要使用反变量加权 (IVW) 方法,以评估因果关系,以 95% 置信区间 (CI) 的几率比率 (OR) 呈现结果.

主要成果:

加勒-4 (Gal-4) 水平与DR (OR=1.068) 和PDR (OR=1.084) 的风险增加存在因果关系.
加勒-3 (Gal-3) 对严重非扩散性DR (SNPDR) (OR=1.455) 的风险表现出因果关系.
加列-3结合蛋白与较高的SNPDR风险 (OR=1.295) 有因果关联,而加列-9 (Gal-9) 与较低的SNPDR风险 (OR=0.669) 有关.

结论:

加勒-4 (Gal-4) 水平与糖尿病视网膜病变 (DR) 和增殖性DR (PDR) 的风险增加有因果关系.
加勒-3 (Gal-3) 和加勒-3结合蛋白因果关系有助于严重非扩散性DR (SNPDR) 的风险.
加勒-9 (Gal-9) 与严重非扩散性DR (SNPDR) 的风险降低存在因果关系.

关键词:

盖莱克酸是一种质蛋白质.门德尔的随机化有因果关系的因果关系.糖尿病视网膜病变糖尿病视网膜病变

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