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Updated: Aug 2, 2026

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Published on: September 28, 2017

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一个高度敏感的蛋白质-RNA交联质谱工作流程,具有增强的结构建模潜力

Chris P Sarnowski1,2, Anna Knörlein3, Tebbe de Vries4

  • 1Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, 8093 Zurich, Switzerland.

Nucleic acids research
|June 18, 2025
PubMed
概括

这项研究增强了稳定同位素标记RNA与质谱法 (CLIR-MS) 结合的交叉链接,增加了检测到的蛋白质-RNA交叉链接. 改进的CLIR-MS管道为整合性结构生物学中的结构约束提供了距离.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...