间膜颗粒类固醇注射后的外周组织反应:一系列病例和系统性审查
Reza Ehsanian1, Deion Ellis2, Lillian Dennison3
1Department of Anesthesiology & Critical Care Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
概括
膜间外膜颗粒状皮质类固醇注射 (ILEPSI) 可能导致外膜空间的颗粒状状反应. 这项研究研究了脊柱减压手术后的这些组织变化,揭示了ILEPSI和观察到的外周反应之间的潜在联系.
科学领域:
- 脊柱外科手术 脊柱外科手术
- 疼痛管理 疼痛管理
- 组织病理学 组织病理学
背景情况:
- 腰部根部疼痛通常通过介膜外周细粒体皮质类固醇注射 (ILEPSI) 进行管理.
- 在ILEPSI后,关于外周膜组织变化的文献有限.
- 了解这些变化对于临床影响至关重要.
研究的目的:
- 在经过脊柱减压的患者中,在ILEPSI后记录粗体和组织学的外周膜组织变化.
- 将这些发现与现有文献进行比较.
主要方法:
- 在ILEPSI后,四名接受脊柱减压手术的患者的回顾性病例系列.
- 在PROSPERO.注册的系统文献审查.
- 外科医生没有看到注射细节和研究目标.
主要成果:
- 手术活检揭示了四名ILEPSI后患者的外周腔空间中的"颗粒状细胞样反应".
- 在文献综述中没有发现类似的外围注射反应.
- 在皮肤学文献中发现了类似的反应.
结论:
- 在ILEPSI后观察到的外周"颗粒状状状反应"是一种新发现.
- 这些反应类似于已知组织对颗粒状皮质类固醇的反应.
- 建议ILEPSI与这些外周皮质组织反应之间存在潜在的关联.
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