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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

54
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
54
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

2.4K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
2.4K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.3K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

623
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
623
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

173
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
173
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

614
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
614

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相关实验视频

Updated: Sep 19, 2025

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

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补性水炎:病变的发生

Axel Villani

    European journal of dermatology : EJD
    |June 18, 2025
    PubMed
    概括

    补腺炎 (HS) 是一种免疫媒介的皮肤疾病. 研究正在探索HS中遗传学,微生物群和免疫反应的作用,以改进治疗方法.

    科学领域:

    • 免疫皮肤学 免疫皮肤学
    • 微生物组研究的研究.
    • 皮肤疾病的遗传学

    背景情况:

    • 补腺炎 (HS) 是一种慢性,炎症性皮肤疾病,其特点是毛囊封闭,随后出现疼痛病变.
    • 遗传因素,包括玛分泌酶复合体的突变和角质细胞功能障碍,在HS患者的一个子集中都存在影响.
    • 在HS中观察到皮肤微生物群失生症,但细菌在疾病发病过程中的确切作用仍未确定.

    研究的目的:

    • 为了阐明基因,微生物和免疫因素在腺炎中复杂的相互作用.
    • 了解HS患者皮肤病变中的先天性和适应性免疫反应的动态.
    • 为了确定更有效的HS治疗的潜在治疗点.

    主要方法:

    • 审查有关HS病变的当前文献,包括遗传关联和微生物组研究.
    • 在受伤皮肤中分析免疫细胞透和炎症通路.
    • 研究特定细菌物种或群体在HS发展中的作用.

    主要成果:

    • 综合性硬化症涉及与先天性和适应性免疫细胞的混合炎症反应.
    • 遗传倾向和角质细胞异常有助于HS.
    • 微生物群失生症存在,但其在HS的致病作用尚未完全确立.
    关键词:
    在B细胞中,B细胞是这就是T细胞.性炎是一种补充性性炎.我们的微生物群.病变的发生和发病.

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    Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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    结论:

    • 对HS病变的全面理解对于开发超越当前抗TNF和抗IL-17治疗的向疗法至关重要.
    • 需要进一步的研究来澄清皮肤微生物群在HS中的确切作用.
    • 研究HS复杂的免疫动态可能会导致新的治疗策略.