对药物相关问题的综合性方法,从性别的角度来看,导致紧急诊所的访问
Concepción Marín-Barcena1, Mireia Puig-Campmany2, Jesús Ruiz-Ramos3
1Departamento de Farmacología, Universidad Autónoma de Barcelona, Bellaterra, España. Sociedad Científica de Investigación Biomédica, Palma de Mallorca, España.
概括
女性,特别是老年妇女,更频繁地前往急诊室治疗与药物相关的问题 (MRP). 在MRP诊断和药物类型中存在显著的性别差异,突出了进一步研究的需要.
科学领域:
- 药物监督 药物监督 药物监督
- 临床药理学 临床药理学
- 公共卫生 公共卫生
背景情况:
- 与药物相关的问题 (MRP) 是急诊室 (ED) 访问的一个重要原因.
- 了解与MRP相关的ED访问中的人口差异,如性别,对于有针对性的干预至关重要.
研究的目的:
- 为了比较与MRP相关的诊断和罪祸首药物类型,导致ED访问,按性别分层.
- 为了确定与MRP相关的ED访问的特定模式,男性与女性相比.
主要方法:
- 在2021-2022年期间,对1611名成人患者进行了回顾性观察性研究,这些患者因MRP而访问ED.
- 数据收集包括社会人口统计和临床变量,MRP诊断和罪祸首药物.
- 统计分析采用二项式分布测试和二元逻辑回归.
主要成果:
- 妇女占MRPED访问的50%以上,这一比例随着年龄的增长而增加.
- 在MRP诊断 (例如腹,无意中毒,电解质失衡) 和罪祸首药物类 (神经,心血管,抗感染系统) 中观察到基于性别的显著差异.
- 女性经历了与影响神经,心血管和抗感染系统的药物相关的MRP的更高率.
结论:
- 在导致紧急诊所访问的MRP类型中存在实质性的基于性别的差异.
- 这些发现强调了持续研究的必要性,以制定旨在减少这些与药物相关危害的性别差异的策略.
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