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Updated: Jul 24, 2026

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对BPA替代品的等效和人体相关混合物的高通量转录组学分析揭示了体外添加效应

Geronimo Matteo1,2, Eunnara Cho1, Marc Rigden1

  • 1Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.

Archives of toxicology
|June 18, 2025
PubMed
概括

混合物中的双甲 (BPA) 替代品显示添加性内分泌干扰作用. 高通量转录组学揭示了常见的作用模式,并确定了有效的BPA替代品,支持混合物毒性评估.

关键词:
内分泌干扰物 干扰内分泌干扰物混合物 混合物 混合物强度 强度 强度 强度监管毒理学 监管毒理学文字转录学 (Transcriptomics) 是一个学科.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...