加巴类药物使用与长期阿片类药物使用者声称的脆弱性变化之间的关联
Jordan Westra1, Mukaila Raji2, Jacques Baillargeon3
1Department of Biostatistics and Data Science, School of Public and Population Health, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555, USA. jrwestra@utmb.edu.
Drugs & aging
|June 18, 2025
概括
长期使用阿片类药物与 gabapentinoids 结合使用或单独使用这两种药物,与医疗保险受益者的脆弱性增加有关. 这与那些不使用这些药物的脆弱性略有下降形成鲜明对比.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 虚弱是老年人不良健康结果的重要预测因素.
- 长期使用阿片类药物在医疗保险受益者中很常见,通常用于慢性疼痛管理.
- gabapentinoids 经常与阿片类药物一起处方,这引发了人们对结合作用的担忧.
研究的目的:
- 调查阿片类药物和 gabapentinoids 的使用与脆弱性变化之间的联系.
- 根据同时使用 gabapentinoid 检查长期阿片类药物使用者的脆弱性轨迹.
主要方法:
- 一项使用2014-2020年医疗保险数据的纵向研究.
- 包括长期使用阿片类药物,有3年的医疗保险A,B和D部分资格,并且以前没有使用过 gabapentinoid.
- 在回顾期,暴露期 (阿片类药物和/或 gabapentinoid 使用) 和使用线性和多项式回归的结果期之间评估脆弱性变化.
主要成果:
- 虽然整体脆弱性变化很小,但使用阿片类药物和/或 gabapentinoids 的组体验到脆弱性增加.
- 仅使用阿片类药物的人的脆弱性增加了0.0040,仅使用 gabapentinoid的人增加了0.0136,联合使用者增加了0.0142.
- 与非使用者相比,所有使用毒品的群体都表现出明显增加的脆弱性增加的几率.
结论:
- 与长期阿片类药物或单独使用两种药物同时使用 gabapentinoids 与更大的虚弱进展有关.
- 这些发现突出了与脆弱老年人群的联合药物治疗相关的潜在风险.
- 需要进一步的研究来探索这些药物组合对衰老和健康的机制和临床影响.
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