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Updated: Sep 19, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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新型氨基-树脂用于水基固相合成

Christina Uth1, Sascha Knauer2, Olga Avrutina3

  • 1Sulfotools GmbH, Rüsselsheim, Germany. uth@sulfotools.com.

Methods in molecular biology (Clifton, N.J.)
|June 18, 2025
PubMed
概括

这项研究引入了一种新的,环保的固体支,用于水性介质中的合成. 树脂可以实现可持续的组合,减少生物大分子生产中危险溶剂的使用.

关键词:
水性固体相合成合成斯莫克氨基酸是氨基酸中的一种.与水相容的树脂与水相容.在水中溶解的保护性组.

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Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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