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定义斑块性牛皮的治疗缓解:国家牛皮基金会的一致声明
April W Armstrong1, George C Gondo2, Joseph F Merola3
1Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles.
JAMA dermatology
|June 18, 2025
概括
在斑块性牛皮的治疗期间缓解的共识定义建立了. 它要求患者在接受治疗期间至少六个月保持0%的身体表面积或0的调查员全球评估.
科学领域:
- 皮肤病学和免疫学
- 临床试验设计 临床试验设计
- 牛皮研究 牛皮研究
背景情况:
- 确定斑块性牛皮的治疗期缓解对于一致的患者应答基准测试至关重要.
- 标准化定义有助于共享理解和有效的牛皮管理.
研究的目的:
- 建立基于共识的关于斑块性牛皮治疗期缓解的定义.
- 利用多个阶段的Delphi倡议,涉及各种利益相关者.
主要方法:
- 对缓解的定义进行了系统的文献审查.
- 一个两阶段的Delphi过程涉及Delphi前面试和医生调查.
- 考虑的结果措施包括BSA,IGA,PGA×BSA和PASI分数.
主要成果:
- 92个利益相关者,包括患者和医生,参与了协商一致的过程.
- 患者将缓解定义为治疗期间没有牛皮的迹象/症状.
- 在治疗期间的缓解定义为0%BSA或IGA0至少6个月在治疗期间.
结论:
- 一个德尔菲的共识过程建立了一个明确的治疗缓解在斑块牛皮的定义.
- 该定义要求至少六个月的身体表面积 (BSA) 或调查员全球评估 (IGA) 为0%.
- 这种标准化基准适用于研究和临床实践环境.
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