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Updated: Sep 19, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

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ZC3H4通过防止在非编码RNA位点发生转录复制冲突来维护基因组完整性

Yann Frey1, Liana Goehring2, Majd Haj1

  • 1The David and Inez Myers Laboratory for Cancer Research, Department of Human Molecular Genetics and Biochemistry, Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

Science advances
|June 18, 2025
PubMed
概括

含有4 (ZC3H4) 蛋白质的CCCH型指抑制非编码RNA (ncRNA) 爆发,防止DNA损伤并保持基因组稳定性. 它的缺失通过促进R循环和转录-复制冲突而增加复制压力.

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