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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Updated: Sep 19, 2025

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

使用功能性超声波进行移动人脑成像.

Sadaf Soloukey^1,2, Luuk Verhoef¹, Frits Mastik¹

¹Department of Neuroscience, Erasmus MC, Wytemaweg 80, 3015 CN, Rotterdam, Netherlands.

Science advances

|June 18, 2025

概括

功能性超声波成像 (fUSi) 现在允许在像行走这样的自然行为中实时监测大脑. 这种移动神经成像技术即使在高运动时也显示一致的信号,为新的临床和神经科学研究铺平了道路.

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Last Updated: Sep 19, 2025

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow

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Published on: March 15, 2021

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

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Published on: July 12, 2012

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
医疗成像医学成像

背景情况:

在自然环境中研究人类大脑是当前神经成像方法的挑战.
需要移动神经成像技术来克服传统的固定扫描仪的局限性.
功能性超声波成像 (fUSi) 为实时大脑活动监测提供了一个有希望的途径.

研究的目的:

为了证明实时功能超声波成像 (fUSi) 在自然行为,特别是行走期间的可行性.
为了验证在移动过程中获得的fUSi信号与既有的神经成像技术相比.
为了评估fUSi的长期稳定性和可靠性,在一个头骨植入物的人身上.

主要方法:

使用了经过临床批准的声光头骨植入物,以实现超快的超声波访问.
雇佣了个性化的3D打印头盔,以便在移动期间稳定地放置fUSi探头.
综合光学跟踪用于功能磁共振成像 (fMRI) 的交叉模式验证,以及用于行为范式的面部跟踪.
应用先进的信号处理来从fUSi数据中提取血液动力学反应.

主要成果:

在20个月的时间里,从大脑活动中获得了一致和可靠的fUSi信号.
在包括行走在内的高运动活动中,证明了成功的实时fUSi监控.
通过与fMRI和行为跟踪进行交叉模式比较,验证了fUSi发现.

结论:

实时fUSi是一种可行的移动神经成像技术,用于研究自然行为期间的大脑活动.
开发的方法结合了专门的硬件和先进的处理,可以在现实世界中进行强大的大脑监测.
这一进步代表了利用fUSi在临床应用和基础神经科学研究方面迈出的重要一步.