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Updated: Sep 19, 2025

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基于结构设计的PROTACS用于降解可溶性环氧化酶的降解

Julia Schönfeld1, Steffen Brunst1,2, Ludmila Ciomirtan3

  • 1Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany.

Journal of medicinal chemistry
|June 18, 2025
PubMed
概括

研究人员开发了一种新型的PROTAC来降解可溶性环氧化酶 (sEH),这是一种与炎症和阿尔茨海默病进展有关的酶. 这种有针对性的方法有效地减少了SEH活动,提供了一个新的治疗策略.

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