尿液度低与COVID-19住院患者的非甲状腺疾病综合征有关
Sara Moreira Anunciação1,2, Renata de Oliveira Campos1,2,3, Fabyan Esberard de Lima Beltrão4,5,6
1Departamento de Biorregulação, Instituto de Saúde e Ciências, Universidade Federal da Bahia, Salvador, BA, Brasil.
Archives of endocrinology and metabolism
|June 18, 2025
概括
尿液度 (USC) 低与住院COVID-19患者的非甲状腺疾病综合征 (NTIS) 有关. 这一发现突出了.
科学领域:
- 内分泌学和新陈代谢学
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- COVID-19可能导致复杂的代谢障碍.
- 非甲状腺疾病综合征 (NTIS) 是一种影响严重疾病期间甲状腺激素水平的疾病.
- 是一种必不可少的微量元素,在免疫功能和新陈代谢中起着重要的作用.
研究的目的:
- 为了评估住院成人COVID-19患者的尿度 (USC).
- 调查USC与非甲状腺疾病综合征 (NTIS) 的存在之间的关系.
- 在这个患者队列中探索USC和炎症标志物之间的相关性.
主要方法:
- 在2020年6月至8月期间住院的121名成年COVID-19患者的前性研究.
- 尿液和血清样本是在症状出现后48小时内采集的.
- 用ICP-MS和NTIS测量的尿度 (USC),以特定的甲状腺激素水平来定义.
主要成果:
- 非甲状腺疾病综合征 (NTIS) 在5.7%的患者中存在.
- 在NTIS和尿度的最低三位数之间发现了显著的关联 (尿含量<25μg/L,p=0.008).
- 甲状腺炎是最常见的甲状腺并发症 (23.9%),与USC没有显著的关联.
结论:
- 该研究表明,在住院COVID-19患者中,尿液度低 (USC) 和非甲状腺疾病综合征 (NTIS) 之间存在明显的关联.
- 这些发现表明状态在严重COVID-19期间的NTIS病理生理学中可能发挥作用.
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