与热应激和野火烟雾暴露相关的不良出生结果在怀孕前和怀孕期间
Roxana Khalili1, Yisi Liu1, Yan Xu1
1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, United States.
Environmental science & technology
|June 18, 2025
概括
预孕前的热量和野火烟雾暴露增加了对孕期婴儿出生小的风险,特别是在脆弱的社区. 气候脆弱性显著改变了热应激对婴儿大小的影响.
科学领域:
- 环境流行病学环境流行病学
- 生殖健康 生殖健康
- 适应气候变化 适应气候变化
背景情况:
- 全球气温上升和野火事件的增加造成了严重的环境压力.
- 产前和怀孕前对环境危害的暴露与不良出生结果有关.
- 邻近地区的社会经济和气候脆弱性可能会加剧健康风险.
研究的目的:
- 检查热应激和野火烟雾暴露和不良出生结果之间的关联.
- 调查邻里气候脆弱性是否会改变这些关联.
- 评估三个月对婴儿大小和出生体重的特定影响.
主要方法:
- 环境和社会压力因素对母亲和发育风险的分析队列 (N=713).
- 一般化的线性模型用于评估暴露与怀孕年龄小 (SGA),低出生体重 (LBW) 和芬顿生长z-scores之间的关联.
- 气候脆弱性指数用于测试效果修改.
主要成果:
- 怀孕前的热应激和野火烟雾暴露与SGA的几率增加有关.
- 生活在高气候脆弱性社区显著改变了热应激效应,几乎使SGA几率翻了一番.
- 第三个三个月的暴露表明LBW的几率降低了,而整体的怀孕暴露与婴儿尺寸较小有关 (SGA,Fenton z-scores).
结论:
- 邻近地区的气候脆弱性作为热应激对SGA的影响的显著影响修饰剂.
- 关键发育窗口期间的环境暴露会影响出生结果.
- 社区的适应能力可能对母亲和儿童健康的气候变化适应性至关重要.
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