肺癌中间歇性肺异常的患病率和预后意义:一个元分析
Ruiyuan Yang1, Haoyu Wang1, Dan Liu1
1Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041 Sichuan, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu 610041 Sichuan, China.
Lung cancer (Amsterdam, Netherlands)
|June 18, 2025
概括
间歇性肺异常 (ILAs) 在肺癌患者中很常见,影响生存和治疗结果. 早期识别和标准化报告ILAs对于改善患者护理至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 肺癌查 (LCS) 经常将间歇性肺异常 (ILA) 确定为偶然发现.
- 虽然在肺癌研究中注意到了ILA,但它们的特定关系和影响仍未得到充分研究.
研究的目的:
- 为了调查肺癌患者中ILAs的患病率.
- 确定ILAs对肺癌预后和治疗结果的影响.
主要方法:
- 一个系统的审查和对PubMed,Web of Science,Embase和Scopus的研究进行元分析.
- 计算了聚合流行率,赔率比率 (ORs) 和危险比率 (HRs).
- 研究遵守PRISMA指南和PROSPERO注册的情况.
主要成果:
- 分析了24项涉及7859名患者的研究.
- 肺癌中ILA的患病率为17% (未经调整) 和9% (经调整),主要模式是网化和地玻璃衰减.
- ILA与总生存率降低 (HR=2.01) 和检查点抑制性肺炎 (OR=2.86) 和辐射性肺炎 (OR=2.98) 的风险增加相关.
结论:
- 间歇性肺异常 (ILAs) 是肺癌患者的重要发现.
- ILA与较差的治疗结果和生存率有关.
- 在CT扫描中标准化的ILA识别和报告对于临床管理至关重要.
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