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血液瘤负载:结合生物标志物来增加知情患者的比例

E Dathathri¹, A Nanou¹, F-C Bidard²

¹Department of Medical Cell Biophysics, TechMed Center, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.

|June 18, 2025

概括

血液瘤负载 (BTL) 结合了循环瘤细胞 (CTC) 和瘤衍生的细胞外囊泡 (tdEV) 以更可靠的癌症评估. 这一新指标改善了对转移性乳腺癌和前列腺癌患者的治疗反应评估和标检测.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
癌症的诊断癌症的诊断

背景情况:

循环瘤细胞 (CTC) 和瘤衍生的细胞外囊泡 (tdEV) 与患者的结果相关,但往往不常见.
由于患者血液样本中CTC的数量很少,因此对CTC的准确评估具有挑战性.
需要一种综合度量来提高基于血液的癌症评估的可靠性.

研究的目的:

引入和验证一个新的指标,血瘤负载 (BTL),结合CTC和tDEVs.
评估BTL在评估治疗反应和确定治疗目标方面的有用性.
提高符合可靠基于血液的癌症评估的患者比例.

主要方法:

从98名转移性乳腺癌 (mBC) 和157名割抵抗性前列腺癌 (CRPC) 患者中收集了CTC和tdEV计数.
通过整合CTC和tDEV计数来计算BTL.
在mBC中对人类表皮生长因子受体2 (HER2) 表达和CRPC患者治疗反应的评估BTL.

主要成果:

在mBC患者中,BTL增加了HER2阳性检测,从35% (单独CTC) 增加到78% (BTL).
与单独使用CTC或tDEV相比,BTL在CRPC患者的整体存活期中表现出更好的Cox危险比率.
在CRPC患者中,BTL下降表明了45%的治疗反应,而增加表明了9%的进展.

结论:

血液瘤负载 (BTL) 显著提高了评估治疗反应和检测治疗目标的可靠性.
BTL提高了可以进行可靠的血液癌症评估的患者的百分比.
这种综合生物标志物方法为癌症管理和监测提供了更强大的工具.

关键词:

接受接受接受血液瘤负载 (BTL) 是指血液中的瘤负载.循环中的瘤细胞.人类表皮生长因子受体2 (HER2)图像分析图像分析来自瘤的细胞外囊泡.

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