关于更年期激素替代疗法,肉症和肉症相关参数之间的关系的系统综述
Marc F Österdahl1, Mary Ni Lochlainn1, Carly Welch1
1Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, United Kingdom; Department of Ageing and Health, Guy's & St Thomas NHS Foundation Trust, London SE1 7EH, United Kingdom.
Maturitas
|June 18, 2025
概括
更年期荷尔蒙替代疗法 (HRT) 没有显示出对与年龄相关的肌肉质量损失 - - 麻症 - - 有益的一致证据. 审查的研究存在方法上的缺陷,并使用过时的HRT配方,对肉症的定义没有共识.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 肌肉生理学 肌肉生理学
背景情况:
- 已知更年期激素替代疗法 (HRT) 对骨健康有益.
- 荷尔蒙回血疗法对肉症,与年龄相关的肌肉质量下降的影响尚不清楚.
- 本综述研究了绝经后妇女的HRT和肉症之间的关系.
研究的目的:
- 系统地审查有关更年期荷尔蒙替代疗法 (HRT) 对肉类的影响的证据.
- 评估HRT对肌肉力量,体力表现和肌肉量的影响.
主要方法:
- 随机对照试验 (RCT) 和观察性研究的系统审查.
- 在主要数据库 (Ovid Medline,Embase,CINAHL,Web of Science) 进行的搜索.
- 主要结局:HRT对萨尔科佩尼亚的影响 (使用共识标准);次要结局:握力,体能,肌肉量.
主要成果:
- 包括43项研究;没有一个使用了对肉类的现代共识定义.
- 在二次结果 (握力,身体表现,肌肉量) 上,HRT对HRT益处的证据在RCT和观察性研究中不一致.
- 偏差和方法缺陷的高风险普遍存在;较旧的HRT配方是常见的.
结论:
- 目前的证据并不总是支持HRT用于预防或治疗肉症.
- 方法上的局限性和使用过时的HRT配方阻碍了最终的结论.
- 需要使用标准化定义和现代HRT配方进行进一步的研究.
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