表观遗传学:环境暴露与自身免疫性疾病之间的联系
Wenhui Zhou1, Bo Zhang1, Ming Zhao1
1Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China; Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
环境因素和表观遗传学显著影响自身免疫性疾病 (AIDs). 了解这些相互作用是有效预防和治疗AIDs的关键.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 自身免疫性疾病 (AID) 是一种复杂的疾病,患病率和死亡率很高.
- 遗传和环境因素都与艾滋病的发病有关.
- 表观遗传学作为环境刺激和基因表达之间的关键联系.
研究的目的:
- 审查与AIDs相关的环境因素.
- 探索这些因素在AID发展中的作用及其与遗传学的相互作用.
- 检查环境因素对表观遗传修饰的影响.
主要方法:
- 文献综述综合了有关艾滋病,环境因素和表观遗传学的最新发现.
- 讨论评估环境风险之间的因果关系的工具.
- 探索用于疾病预防的临床干预试验.
主要成果:
- 环境暴露,包括化学,物理和生物因素,与AIDs有关.
- 涉及的表观遗传修饰包括DNA甲基化,基因素修饰和microRNAs.
- 关于特定的环境因素及其对AIDs的表观遗传影响,存在一个知识差距.
结论:
- 了解表观遗传学和环境风险因素之间的相互作用对于AIDs至关重要.
- 准确的机制性见解对于及时预防和改善治疗结果至关重要.
- 需要进一步的研究来弥合环境因素,表观遗传学和艾滋病之间的差距.
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